Marcus, N. (2004). An overview of the impacts of eutrophication and chemical pollutants on copepods of the coastal zone. Zoological Stud. 43, 211–217. Available at: https://zoolstud.sinica.edu.tw/Journals/43.2/211.pdf. Marshall, D. J., Dong, Y.-w., McQuaid, C. D., and Williams, G. A. (2011). Thermal adaptation in the intertidal snail Echinolittorina malaccana contradicts current theory by revealing the crucial roles of resting metabolism. J. Exp. Biol. 214, 3649–3657. doi: 10.1242/jeb.059899 Schulte, P. M., Healy, T. M., and Fangue, N. A. (2011). Thermal performance curves, phenotypic plasticity, and the time scales of temperature exposure. Integr. Comp. Biol. 51, 691–702. doi: 10.1093/icb/icr097 Simboura, N., Pavlidou, A., Bald, J., Tsapakis, M., Pagou, K., Zeri, C., et al. (2016). Response of ecological indices to nutrient and chemical contaminant stress factors in Krishna et al. 10.3389/fmars.2024.1481734Meadows, P. S., Meadows, A., and Murray, J. M. (2012). Biological modi?ers of marine benthic seascapes: Their role as ecosystem engineers. Geomorphology 157, 31– 48. doi: 10.1016/j.geomorph.2011.07.007 Miller, S. H., Zarate, S., Smith, E. H., Gaylord, B., Hosfelt, J. D., and Hill, T. M. (2014). Effect of elevated pco2 on metabolic responses of porcelain crab (Petrolisthes cinctipes) larvae exposed to subsequent salinity stress. PloS One 9, e109167. doi: 10.1371/ journal.pone.0109167 Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., and Group P (2009). Preferred reporting items for systematic reviews and meta-analyses: the prisma statement. Ann. Internal Med. 151, 264–269. doi: 10.7326/0003-4819-151-4-200908180-00135 Murphy, G. E., Romanuk, T. N., and Worm, B. (2020). Cascading effects of climate change on plankton community structure. Ecol. Evol. 10, 2170–2181. doi: 10.1002/ ece3.v10.4 Mustafa, S. A., Davies, S. J., and Jha, A. N. (2012). Determination of hypoxia and dietary copper mediated sub-lethal toxicity in carp, Cyprinus carpio, at different levels of biological organisation. Chemosphere 87, 413–422. doi : 10.1016/ j.chemosphere.2011.12.037 Neale, P. J., Sobrino, C., Segovia, M., Mercado, J., Leo?n, P., Corte?s, M., et al. (2014). Effect of co2, nutrients and light on coastal plankton. i. abiotic conditions and biological responses. Aquat. Biol. 22, 25–41. doi: 10.3354/ab00587 Nikulina, A., and Dullo, W.-C. (2009). Eutrophication and heavy metal pollution in the ?ensburg fjord: a reassessment after 30 years. Mar. pollut. Bull. 58, 905–915. doi: 10.1016/j.marpolbul.2009.01.017 Paerl, H. W. (1997). Coastal eutrophication and harmful algal blooms: Importance of atmospheric deposition and groundwater as “new” nitrogen and other nutrient sources. Limnology Oceanography 42, 1154–1165. doi: 10.4319/lo.1997.42.5_part_2.1154 Pansch, C., and Hiebenthal, C. (2019). A new mesocosm system to study the effects of environmental variability on marine species and communities. Limnology Oceanography: Methods 17, 145–162. doi: 10.1002/lom3.10306 Pardo, J. C., and Costa, T. M. (2021). Multiple-stressor effects of warming and acidi?cation on the embryonic development of an estuarine ?ddler crab. Estuarine Coast. Shelf Sci. 254, 107296. doi: 10.1016/j.ecss.2021.107296 Pinnegar, J., Polunin, N., Francour, P., Badalamenti, F., Chemello, R., Harmelin- Vivien, M.-L., et al. (2000). Trophic cascades in benthic marine ecosystems: lessons for ?sheries and protected-area management. Environ. Conserv. 27, 179–200. doi: 10.1017/ S0376892900000205 Pirotta, E., Thomas, L., Costa, D. P., Hall, A. J., Harris, C. M., Harwood, J., et al. (2022). Understanding the combined effects of multiple stressors: A new perspective on a longstanding challenge. Sci. Total Environ. 821, 153322. doi: 10.1016/ j.scitotenv.2022.153322 Pörtner, H.-O. (2012). Integrating climate-related stressor effects on marine organisms: unifying principles linking molecule to ecosystem-level changes. Mar. Ecol. Prog. Ser. 470, 273–290. doi: 10.3354/meps10123 Queiro?s, A. M., Fernandes, J. A., Faulwetter, S., Nunes, J., Rastrick, S. P., Mieszkowska, N., et al. (2015). Scaling up experimental ocean acidi?cation and warming research: from individuals to the ecosystem. Global Change Biol. 21, 130– 143. doi: 10.1111/gcb.2014.21.issue-1 Richard, M., Bec, B., Bergeon, L., He?bert, M., Mablouke?, C., and Lagarde, F. (2022). Are mussels and oysters capable of reducing the abundances of Picochlorum sp., responsible for a massive green algae bloom in thau lagoon, France? J. Exp. Mar. Biol. Ecol. 556, 151797. Riedel, G. F., Sanders, J. G., and Breitburg, D. L. (2003). Seasonal variability in response of estuarine phytoplankton communities to stress: Linkages between toxic trace elements and nutrient enrichment. Estuaries 26, 323–338. doi: 10.1007/ BF02695971 Rodrigues, L. C., Van Den Bergh, J. C., Massa, F., Theodorou, J. A., Ziveri, P., and Gazeau, F. (2015). Sensitivity of mediterranean bivalve mollusc aquaculture to climate change, ocean acidi?cation, and other environmental pressures: ?ndings from a producer survey. J. Shell?sh Res. 34, 1161–1176. doi: 10.2983/035.034.0341 Sandifer, P. A., and Sutton-Grier, A. E. (2014). Connecting stressors, ocean ecosystem services, and human health. Natural Resour. Forum 38, 157–167. doi: 10.1111/narf.2014.38.issue-3 Scheffer, M., Carpenter, S., and de Young, B. (2005). Cascading effects of over?shing marine systems. Trends Ecol. Evol. 20, 579–581. doi: 10.1016/j.tree.2005.08.018Frontiers in Marine Science 12Eastern Mediterranean coastal waters. Ecol. Indic. 70, 89–105. doi: 10.1016/ j.ecolind.2016.05.018 Skei, J., Larsson, P., Rosenberg, R., Jonsson, P., Olsson, M., and Broman, D. (2000). Eutrophication and contaminants in aquatic ecosystems. AMBIO: A J. Hum. Environ. 29, 184–194. doi: 10.1579/0044-7447-29.4.184 Smith, V. H., and Schindler, D. W. (2009). Eutrophication science: where do we go from here? Trends Ecol. Evol. 24, 201–207. doi: 10.1016/j.tree.2008.11.009 Soerensen, A. L., Schartup, A. T., Gustafsson, E., Gustafsson, B. G., Undeman, E., and Björn, E. (2016). Eutrophication increases phytoplankton methylmercury concentrations in a coastal sea a Baltic Sea case study. Environ. Sci. Technol. 50, 11787–11796. doi: 10.1021/acs.est.6b02717 Solan, M., and Whiteley, N. (2016). Stressors in the Marine Environment: Physiological and Ecological Responses; Societal Implications (Oxford University Press, Oxford: Oxford University Press). Song, Y., Guo, Y., Liu, H., Zhang, G., Zhang, X., Thangaraj, S., et al. (2022). Water quality shifts the dominant phytoplankton group from diatoms to dino?agellates in the coastal ecosystem of the Bohai Bay. Mar. pollut. Bull. 183, 114078. doi: 10.1016/ j.marpolbul.2022.114078 Stelzenmüller, V., Rehren, J., Örey, S., Lemmen, C., Krishna, S., Hasenbein, M., et al (2024). Framing future trajectories of human activities in the German North Sea to inform cumulative effects assessments and marine spatial planning. Journal of Environmental Management 349, 119507. Stewart, R. I., Dossena, M., Bohan, D. A., Jeppesen, E., Kordas, R. L., Ledger, M. E., et al. (2013). Mesocosm experiments as a tool for ecological climate-change research. Adv. Ecol. Res. 48, 71–181. doi: 10.1016/B978-0-12-417199-2.00002-1 Stockbridge, J., Jones, A. R., and Gillanders, B. M. (2020). A meta-analysis of multiple stressors on seagrasses in the context of marine spatial cumulative impacts assessment. Sci. Rep. 10, 11934. doi: 10.1038/s41598-020-68801-w Stueckle, T. A. (2008). An Evaluation of the Non-Target Effects of Mosquito Control Pesticides on Uca Pugnax Physiology, Limb Regeneration and Molting Processes (West Virginia University, Morgantown, USA: West Virginia University). Sundbäck, K., Petersen, D. G., Dahllöf, I., and Larson, F. (2007). Combined nutrient– toxicant effects on a shallow-water marine sediment system: sensitivity and resilience of ecosystem functions. Mar. Ecol. Prog. Ser. 330, 13–30. doi: 10.3354/meps330013 Tate, R. D., Benkendorff, K., Ab Lah, R., and Kelaher, B. P. (2017). Ocean acidi?cation and warming impacts the nutritional properties of the predatory whelk, dicathais orbita. J. Exp. Mar. Biol. Ecol. 493, 7–13. doi: 10.1016/j.jembe.2017.03.006 Thomsen, J., Casties, I., Pansch, C., Körtzinger, A., and Melzner, F. (2013). Food availability outweighs ocean acidi?cation effects in juvenileMytilus edulis: laboratory and ?eld experiments. Global Change Biol. 19, 1017–1027. doi: 10.1111/gcb.2013.19.issue-4 Thrush, S. F., Hewitt, J. E., Gladstone-Gallagher, R. V., Savage, C., Lundquist, C., O’Meara, T., et al. (2021). Cumulative stressors reduce the self-regulating capacity of coastal ecosystems. Ecol. Appl. 31, e02223. doi: 10.1002/eap.v31.1 Turschwell, M. P., Connolly, S. R., Schäfer, R. B., De Laender, F., Campbell, M. D., Mantyka-Pringle, C., et al. (2022). Interactive effects of multiple stressors vary with consumer interactions, stressor dynamics and magnitude. Ecol. Lett. 25, 1483–1496. doi: 10.1111/ele.14013 Vihtakari, M., Hendriks, I. E., Holding, J., Renaud, P. E., Duarte, C. M., and Havenhand, J. N. (2013). Effects of ocean acidi?cation and warming on sperm activity and early life stages of the mediterranean mussel (Mytilus galloprovincialis). Water 5, 1890–1915. doi: 10.3390/w5041890 Villar-Argaiz, M., Medina-Sa?nchez, J. M., Biddanda, B. A., and Carrillo, P. (2018). Predominant nonadditive effects of multiple stressors on autotroph c: N: P ratios propagate in freshwater and marine food webs. Front. Microbiol. 9, 69. doi: 10.3389/ fmicb.2018.00069 Wake, B. (2019). Experimenting with multistressors. Nat. Climate Change 9, 357– 357. doi: 10.1038/s41558-019-0475-z Wang, W.-X., and Dei, R. C. (2001). Effects of major nutrient additions on metal uptake in phytoplankton. Environ. Pollut. 111, 233–240. doi: 10.1016/S0269-7491(00) 00071-3 Wiegner, T. N., Seitzinger, S. P., Breitburg, D. L., and Sanders, J. G. (2003). The effects of multiple stressors on the balance between autotrophic and heterotrophic processes in an estuarine system. Estuaries 26, 352–364. doi: 10.1007/BF02695973 Zhang, J. (2000). Evidence of trace metal limited photosynthesis in eutrophic estuarine and coastal waters. Limnology Oceanography 45, 1871–1878. doi: 10.4319/ lo.2000.45.8.1871frontiersin.org